When in Vatican City, one is somewhat obligated to visit Saint Peter's Basilica (the largest church in the world by interior area). The plans for the basilica were ordered by Pope Nicholas V in the 15th century and construction initiated by Pope Julius II in 1506. Work on the basilica completed over a century later in 1626. Michelangelo was one of the principle designers, along with Donato Bramante and Carlo Maderno.
Standing in St. Peter's Square was pretty cool. But the basilica itself was just amazing. We chose to pay for the dome tour and it was well worth it. This visit was one of the highlights of our Rome experience. Pictures don't really do it justice, but I've captured some highlights below (apologies for the quantity).